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Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell Disease

Study acronym: LidoVOC
StatusRecruiting
PhasePhase 3
Started2026-07-03
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 5 months later Mar 1, 2028 → Aug 3, 2028
See other at-risk trials from Nantes University Hospital

Amendment history

2026-09-08
Study Status, Eligibility, Contacts/Locations v4
Study sites11→12
Eligibility criteria+44 characters
[...] lin definition Acute or Chronic liver failure with MELD > 19 according to CKD-EPI Acute or Chronic kidney failure with clearance <30mL/min/m2 according to CKD-EPI Body weight <40kg and >120kg Prior inclusion in the study i [...] entilation Altered consciousness with Glasgow coma scale <13 Patient already included in a clinical drug
2026-07-09
Study Status, Contacts/Locations v3
Recruitment opened
Primary completion pushed: 2028-03-01 → 2028-08-03
Completion pushed: 2028-04-01 → 2028-08-03
Start dateestimated 2026-03-01→confirmed 2026-07-03
Study sitesdetails revised at 11 of 11 sites
2025-12-18
Study Status, Outcome Measures v2
Secondary endpointsdetails revised at 2 of 14 entries
2025-12-10
Study Status, Conditions, Arms and Interventions, Outcome Measures, Eligibility v1
Eligibility criteria+5 characters
[...] ad (skull), spine, and/or pelvis, not attributable to other causecauses Acute Chest Syndrome defined by the association of clinical [...] ext of kin informed about the study and having consented to the participation of the patient in the study. If patient is no [...]
Secondary endpointsdetails revised at 1 of 14 entries
Primary endpoints1 entry, revised
Cumulative parenteral opioid dose between randomisationrandomization and discharge from the intensive care unit expressed in morphine milligram equivalent.
2025-11-27
Original filing
The purpose of the study is to determine whether adding lidocaine to standard of care in pain management during severe vaso-occlusive crisis has an effect on the cumulative opioid consumption expressed as morphine milligram equivalent.
Trial Details
NCT Number NCT07274254
Lead Sponsor Nantes University Hospital
Conditions Vaso-Occlusive Pain Episode in Sickle Cell Disease
Enrollment 104 participants
Start Date 2026-07-03
Primary Completion 2028-08-03 (estimated)
Study Completion 2028-08-03 (estimated)
Updated on ClinicalTrials.gov 2026-09-09