Risk-Adapted Omission of Level Va Irradiation in Nasopharyngeal Carcinoma

This is a randomized, phase III, prospective, multi-center trial in newly diagnosed nasopharyngeal carcinoma (NPC) patients without distant metastasis. This study will evaluate whether omitting Level Va irradiation in patients without these risk features does not compromise regional control or survival, with the goal of providing robust evidence to guide further personalization of NPC radiotherapy.

NCT Number	NCT07268690
Lead Sponsor	Fujian Cancer Hospital
Conditions	Nasopharyngeal Carcinoma by AJCC V9 Stage
Enrollment	474 participants
Start Date	2026-01-01
Primary Completion	2028-12-31 (estimated)
Study Completion	2030-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-08