Surgical Timing After Preoperative Hypofractionated Radiotherapy for Localized Extremity and Trunk Soft Tissue Sarcoma

Phase II, national, multicentric, prospective, randomized (1:1) non-inferiority trial with two parallel groups, incorporating a concurrent observational cohort of eligible non-randomized patients, designed to address critical knowledge gaps by prospectively evaluating the safety, efficacy, and feasibility of preoperative ultra-hypofractionated radiotherapy (HFRT) in patients with soft tissue sarcomas (STS) of the extremities and trunk.

NCT Number	NCT07265661
Lead Sponsor	Italian Sarcoma Group Collaborators: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Conditions	Soft Tissue Sarcoma of the Trunk and Extremities
Enrollment	142 participants
Start Date	2026-01-30
Primary Completion	2029-12-01 (estimated)
Study Completion	2035-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-01-06