Efficacy of Inhaled Nitric Oxide in Congenital Diaphragmatic Hernia

This multicenter, prospective, single-arm study aims to evaluate the efficacy of inhaled nitric oxide (iNO) in neonates with congenital diaphragmatic hernia (CDH) and early pulmonary hypertension. Short-term treatment response will be assessed by the changes in oxygenation index and other parameters including echocardiographic parameters at predefined intervals.

NCT Number	NCT07247240
Lead Sponsor	Asan Medical Center Collaborators: Seoul National University Hospital, Severance Hospital, Chungnam National University Hospital
Conditions	Congenital Diaphragmatic Hernia, Pulmonary Hypertension
Enrollment	40 participants
Start Date	2025-11
Primary Completion	2028-12 (estimated)
Study Completion	2028-12 (estimated)
Updated on ClinicalTrials.gov	2025-11-25