A Translational Study for Phenotyping and Endotyping Chinese Patients With NCFBE

Non-cystic fibrosis bronchiectasis (NCFBE) is a chronic respiratory disease characterized by a clinical syndrome of chronic productive cough and recurrent respiratory infections in the presence of abnormal and permanent dilation of the bronchi. Recent epidemiological studies have clearly shown that the prevalence and incidence of NCFBE are quickly rising both in high- and low-income countries. With the increase of prevalence, bronchiectasis brings huge medical and economic burden to the society. In this study, the investigator will perform biomarker assessments and multi-omics analysis on NCFBE patients and healthy participants in China to validate the link of disease pathways to pathophysiological features and uncover the molecular endotypes behind clinical phenotypesof Chinese patients with NCFBE.

NCT Number	NCT07245407
Lead Sponsor	AstraZeneca
Conditions	Non-cystic Fibrosis Bronchiectasis
Enrollment	320 participants
Start Date	2025-10-27
Primary Completion	2027-07-29 (estimated)
Study Completion	2027-07-29 (estimated)
Updated on ClinicalTrials.gov	2026-07-14