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CHEST: A Collaboration With Community HEalth Centers to Implement SmarT for Asthma

Study acronym: CHEST
StatusRecruiting
PhasePhase 4
Started2026-01-06
View on ClinicalTrials.gov ↗
Purpose: This study aims to improve asthma care by helping clinicians at community health centers prescribe a guideline-recommended treatment called SMART (Single Maintenance and Reliever Therapy). The investigators will provide training and resources to clinicians, give feedback on prescribing patterns, and offer educational tools for patients and providers. The investigators will roll out these resources in stages across clinics. The study will measure how well the program helps clinicians prescribe SMART therapy and whether it reduces asthma exacerbations in patients.

Amendment history 1 change detected by DataLookout

2026-08-20
Primary endpoint(s) modified
WasClinician-level adoption (of the SMART implementation bundle), Patient-level Effectiveness (of the SMART implementation bundle)
NowClinic-level effectiveness of the SMART implementation bundle, measured as the proportion of SMART-eligible asthma encounters in which SMART is prescribed, Clinician-level adoption (of the SMART implementation bundle), Patient-level Effectiveness (of the SMART implementation bundle)
Trial Details
NCT Number NCT07241117
Lead Sponsor Washington University School of Medicine
Collaborators: National Heart, Lung, and Blood Institute (NHLBI), Doris Duke Charitable Foundation, Affinia Healthcare, Family Care Health Centers
Conditions Moderate to Severe Asthma
Enrollment 2,000 participants
Start Date 2026-01-06
Primary Completion 2027-11-15 (estimated)
Study Completion 2028-11-15 (estimated)
Updated on ClinicalTrials.gov 2026-08-19