Metformin in Parkinson Disease

The clinical manifestations of Parkinson's disease (PD), a chronic neurodegenerative condition, include resting tremor, hypokinesia, bradykinesia, stiffness and postural instability. These motor symptoms are caused by a selective loss and degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) region, which leads to a dopamine (DA) insufficiency in the striatum

NCT Number	NCT07229651
Lead Sponsor	Tanta University
Conditions	Parkinson Disease
Enrollment	60 participants
Start Date	2025-11-10
Primary Completion	2026-11-20 (estimated)
Study Completion	2027-09-20 (estimated)
Updated on ClinicalTrials.gov	2025-11-21