Clinical Trial

Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)

Recruiting Phase 2
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Summary
This is a randomized, phase II trial comparing staged stereotactic radiosurgery (SSRS) versus fractionated stereotactic radiotherapy (FSRT) in patients with large brain metastases (≥2 cm and ≤5 cm). The study aims to evaluate efficacy, safety, and tumor response between these two standard-of-care radiation approaches.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-11-10.
Status change: Not Yet Recruiting → Recruiting 2026-02-03
Trial Details
NCT Number NCT07227610
Lead Sponsor Medical University of South Carolina
Conditions Brain Metastases, Cancer (With CNS Involvement)
Enrollment 54 participants
Start Date 2026-02-03
Primary Completion 2029-02-03 (estimated)
Study Completion 2030-02-03 (estimated)
Updated on ClinicalTrials.gov 2026-02-05