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Methadone in THA for Post-op Pain and Opioid Reduction

StatusRecruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗

Record History

  1. Trial status: Not Yet Recruiting to Recruiting Study sites: 0 to 1 · Start date changed from estimate of Feb 10, 2026 to Jan 12, 2026v5 Show 2 more changesShow less
    • Study sites: 0 to 1
    • Start date changed from estimate of Feb 10, 2026 to Jan 12, 2026
  2. Start date: Dec 31, 2025 to Feb 10, 2026v4
  3. Start date: Dec 1, 2025 to Dec 31, 2025 Primary completion date: Dec 1, 2026 to Dec 31, 2026 · Completion date: Dec 31, 2026 to Jan 31, 2027v3 Show 2 more changesShow less
    • Primary completion date: Dec 1, 2026 to Dec 31, 2026
    • Completion date: Dec 31, 2026 to Jan 31, 2027
  4. Secondary endpoints: details revised at 1 of 5 entriesv2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This randomized, double-blind controlled trial investigates whether intraoperative intravenous methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total hip arthroplasty under spinal anesthesia with mepivacaine. The primary outcome is patient-reported pain on a visual analog scale (VAS) 30-60 minutes after arrival in the post-anesthesia care unit (PACU). Secondary outcomes include opioid use, pain scores over time, incidence of nausea/vomiting, and quality of recovery. A total of 162 subjects will be enrolled at MUSC surgical sites.
Trial Details
NCT Number NCT07227064
Lead Sponsor Medical University of South Carolina
Conditions Post Operative Pain, Total Hip Arthroplasty
Enrollment 162 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov