Clinical Trial

Methadone Pharmacokinetics in Cardiac Surgery

Not Yet Recruiting Phase 4
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Summary
Cardiac surgery frequently leads to significant postoperative pain, with multiple different drug regimens being utilized (both opioid and non-opioid) in an attempt to alleviate this surgical pain. Methadone is currently one of the drugs that is being utilized to help control the pain. It can be given during and/or after surgery. This study hopes to identify the optimal dose of methadone to use to treat this surgical pain.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2025-11-06; most recent amendment 2026-05-22.
Trial Details
NCT Number NCT07226245
Lead Sponsor Wake Forest University Health Sciences
Conditions Postoperative Pain Management
Enrollment 69 participants
Start Date 2026-09
Primary Completion 2026-12-30 (estimated)
Study Completion 2026-12-30 (estimated)
Updated on ClinicalTrials.gov 2026-05-26