Clinical Trial

Methadone in TKA for Post-op Pain and Opioid Reduction

Recruiting Phase 3
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Summary
This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2025-11-06; most recent amendment 2026-02-02.
Status change: Not Yet Recruiting → Recruiting 2026-02-02
Trial Details
NCT Number NCT07226076
Lead Sponsor Medical University of South Carolina
Conditions Post Operative Pain
Enrollment 162 participants
Start Date 2026-01-08
Primary Completion 2026-12-28 (estimated)
Study Completion 2027-01-15 (estimated)
Updated on ClinicalTrials.gov 2026-02-04