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Methadone in TKA for Post-op Pain and Opioid Reduction

StatusRecruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗

Record History

  1. Trial status: Not Yet Recruiting to Recruiting Study sites: 0 to 1 · Start date changed from estimate of Feb 10, 2026 to Jan 8, 2026v5 Show 2 more changesShow less
    • Study sites: 0 to 1
    • Start date changed from estimate of Feb 10, 2026 to Jan 8, 2026
  2. Start date: Dec 28, 2025 to Feb 10, 2026v4
  3. Start date: Nov 28, 2025 to Dec 28, 2025 Primary completion date: Nov 28, 2026 to Dec 28, 2026 · Completion date: Dec 15, 2026 to Jan 15, 2027v3 Show 2 more changesShow less
    • Primary completion date: Nov 28, 2026 to Dec 28, 2026
    • Completion date: Dec 15, 2026 to Jan 15, 2027
  4. Secondary endpoints: details revised at 1 of 5 entriesv2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.
Trial Details
NCT Number NCT07226076
Lead Sponsor Medical University of South Carolina
Conditions Post Operative Pain
Enrollment 162 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov