Sex Differences in Neurobehavioral Response to THC

This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo).

NCT Number	NCT07225777
Lead Sponsor	Medical University of South Carolina Collaborators: National Institutes of Health (NIH), National Institute on Drug Abuse (NIDA)
Conditions	Cannabis Use Disorder
Enrollment	40 participants
Start Date	2026-04-27
Primary Completion	2027-12-31 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-06