Clinical Trial

Liquid Biopsy for Early Detection of Colorectal Cancer Using Circular RNA

Study acronym: CIRCLE
Recruiting
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Summary
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. This study aims to develop a non-invasive liquid biopsy assay using plasma-derived cell-free circular RNAs (cf-circRNAs) for early and accurate detection of colorectal cancer.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-11-03; most recent amendment 2026-07-06.
Trial Details
NCT Number NCT07224789
Lead Sponsor City of Hope Medical Center
Conditions Colorectal Cancer
Enrollment 600 participants
Start Date 2025-01-15
Primary Completion 2028-06-18 (estimated)
Study Completion 2028-06-18 (estimated)
Updated on ClinicalTrials.gov 2026-07-07