Clinical Trial

Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study

Study acronym: MEND
Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and safety of postoperative oral methadone in patients undergoing spine surgery and collect preliminary data to inform a larger clinical trial that will test the opioid-sparing effects of methadone at 3 months after spine surgery.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-10-24; most recent amendment 2025-12-15.
Status change: Not Yet Recruiting → Recruiting 2025-11-11
Trial Details
NCT Number NCT07222072
Lead Sponsor The Cleveland Clinic
Conditions Post Operative Pain, Spinal Surgery
Enrollment 120 participants
Start Date 2025-11-15
Primary Completion 2027-10 (estimated)
Study Completion 2028-10 (estimated)
Updated on ClinicalTrials.gov 2025-12-17