Clinical Trial

Low Intensity Focused Ultrasound Stimulation in Stroke Patients - Parameter Optimization

Study acronym: LIFUS-OPTIMIZE
Recruiting
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Record status
This record was last updated December 23, 2025 (before its estimated May 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
The goal of this research study is to optimize the parameter of Low-Intensity Focused Ultrasound Stimulation (LIFUS) that is most effective in changing cortical excitability and motor learning skills in patients who suffered a stroke. The researchers hope to answer two questions. * with increasing power, would LIFUS be more effective? * with the same power, what LIFUS timing is the best For Aim 1, the study will compare 8, 4 W/cm\^2 to a zero(sham) stimulation to see if higher power is the better. For Aim 2, the study will compare 500 vs 1000 vs 2000 Hz "timing" to see which one is better.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-10-21.
Status change: Not Yet Recruiting → Recruiting 2025-12-19
Trial Details
NCT Number NCT07220005
Lead Sponsor Duke University
Conditions Stroke, Arm Weakness as a Consequence of Stroke, Upper Extremity Hemiparesis, Upper Extremity Impairments, Upper Extremity Weakness
Enrollment 24 participants
Start Date 2025-12-10
Primary Completion 2026-05-01 (estimated)
Study Completion 2026-06-30 (estimated)
Updated on ClinicalTrials.gov 2025-12-23