A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule

The investigators have developed an inexpensive tool to take pictures in the lower GI tract without sedation and to look for signs of disease. The tool is a capsule, about the size of a fish oil or multi-vitamin supplement, attached to a string. The capsule and string are connected to a motor to allow the capsule to advance up the participant's lower GI tract. The capsule will be inserted into the participant's lower GI tract and advance upward via a slow spiral motion. The capsule is connected to an imaging system that saves and displays the images in real time.

NCT Number	NCT07219537
Lead Sponsor	Massachusetts General Hospital Collaborators: The Leona M. and Harry B. Helmsley Charitable Trust, Dana-Farber Cancer Institute
Conditions	Lynch Syndrome, Crohn Disease, Inflammatory Bowel Diseases, Healthy
Enrollment	30 participants
Start Date	2023-03-27
Primary Completion	2027-12-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-16