The Effect of Thalamic Stimulation on Sleep Oscillations

The thalamus plays a key role in supporting sleep and is also a target of therapeutic stimulation. This project investigates when, where, and how electrical stimulation delivered to the thalamus in humans elicits or disrupts sleep oscillations. This research is a first step to better understand how current neuromodulation therapies affect sleep and may help advance toward new therapies to improve sleep for a wide range of neurological and neuropsychological disorders.

NCT Number	NCT07217080
Lead Sponsor	Massachusetts General Hospital Collaborators: National Institute on Aging (NIA)
Conditions	Sleep, Neuromodulation
Enrollment	50 participants
Start Date	2025-01-06
Primary Completion	2029-11-30 (estimated)
Study Completion	2029-11-30 (estimated)
Updated on ClinicalTrials.gov	2025-10-15