The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study

The goal of this clinical trial is to develop and test the CROSSROADS intervention. CROSSROADS is designed for people who have recently survived an opioid and/or stimulant-related non-fatal overdose and had contact with staff from a Community Paramedic (CP) program. Participants will be randomly placed into one of two groups: 1\) Standard of care from the CP program, or 2) CROSSROADS, which includes CP care plus a Medical-Legal Partnership (MLP). The MLP helps people with legal problems that can affect their health-- like issues with housing or public benefits. Researchers will test if the CROSSROADS intervention reduces drug use and involvement with the criminal legal system. People in the study will be followed for one year and asked to complete surveys at the beginning, and again at 1 month, 6 months, and 12 months.

NCT Number	NCT07216963
Lead Sponsor	Duke University Collaborators: National Institute on Drug Abuse (NIDA)
Conditions	Opioid Use Disorder, Overdose, Drug, Overdose, Substance Use (Drugs, Alcohol)
Enrollment	400 participants
Start Date	2026-09-01
Primary Completion	2029-09-01 (estimated)
Study Completion	2030-08-01 (estimated)
Updated on ClinicalTrials.gov	2026-04-13