Total Neoadjuvant Therapy With PD-1 for Locally Advcancer Rectal Cancer

Research Objective:To investigate the efficacy and safety of the "total neoadjuvant chemoradiotherapy combined with immunotherapy" regimen for the treatment of locally advanced rectal cancer with high-risk features for recurrence. Study Design:A single-arm, multicenter clinical study. Study Population: Patients with locally advanced rectal cancer presenting with high-risk features for local recurrence.

NCT Number	NCT07214142
Lead Sponsor	The First Affiliated Hospital of University of Science and Technology of China
Conditions	Rectal Cancer Patients
Enrollment	30 participants
Start Date	2025-10-01
Primary Completion	2027-12-31 (estimated)
Study Completion	2030-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-10-09