Effect of Theta-burst rTMS Therapy on the Clinical and Cognitive Symptoms of Patients With Therapy Resistant Depression and Response Prediction With Neuroimaging Methods.

The primary aim of the study is to find the combination of neuroimaging-related markers, demographics, and clinical characteristics that predict the response of patients with therapy-resistant depression to theta-burst rTMS treatment. The secondary aim is to monitor the cognitive effects of TMS therapy.

NCT Number	NCT07207239
Lead Sponsor	Semmelweis University
Conditions	Transcranial Magnetic Stimulation, Repetitive, Depression - Major Depressive Disorder
Enrollment	54 participants
Start Date	2025-06-13
Primary Completion	2028-06-13 (estimated)
Study Completion	2028-06-13 (estimated)
Updated on ClinicalTrials.gov	2025-10-03