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A Research Trial to Assess if Cenerimod is Efficacious and Safe to Treat Active Lupus Nephritis on Top of Regular Treatment

Study acronym: LUMIOS
StatusRecruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗

Record History

  1. Re-verified, no change to tracked fieldsv12
  2. Trial sites expanded: 11 → 14 locationsv11
  3. Re-verified, no change to tracked fieldsv10
  4. Study sites: 10 to 11v9
  5. Study sites: 9 to 10v8
  6. Trial sites expanded: 6 → 9 locationsv7
  7. Secondary endpoints revised (2) Eligibility criteria expanded, about 3 wordsv6 Show 1 more changeShow less
    • Eligibility criteria expanded, about 3 words

    See this version in full on ClinicalTrials.gov ↗

  8. Study sites: 2 to 6v5
  9. Trial status: Not Yet Recruiting to Recruiting Study sites: 1 to 2 · Start date changed from estimate of Jan 2026 to Feb 9, 2026v4 Show 2 more changesShow less
    • Study sites: 1 to 2
    • Start date changed from estimate of Jan 2026 to Feb 9, 2026
  10. Study sites: 0 to 1 Start date: Dec 2025 to Jan 2026v3 Show 1 more changeShow less
    • Start date: Dec 2025 to Jan 2026
  11. Re-verified, no change to tracked fieldsv2
  12. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this clinical trial is to learn if cenerimod, on top of regular treatment, works to treat active lupus nephritis in adults with systemic lupus erythematosus and active lupus nephritis. It will also learn about the safety of cenerimod. The main questions it aims to answer are: * Does cenerimod improve kidney function in participants? * What medical problems do participants have when taking cenerimod? Researchers will compare cenerimod to a placebo (a look-alike substance that contains no drug) to see how well cenerimod works when it is added to regular treatment. Participants will: * Take cenerimod or a placebo every day for 76 weeks (approximately 1.5 years), on top of regular treatment. * Visit the clinic every 1 to 3 months for checkups and tests.
Trial Details
NCT Number NCT07201129
Lead Sponsor Viatris Innovation GmbH
Conditions Nephritis, Lupus, Lupus Erythematosus, Systemic
Enrollment 300 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov