Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis

This study will test whether inulin, a type of dietary fiber, can reduce inflammation in older adults with knee osteoarthritis. Inflammation in the body may contribute to both joint pain and the progression of osteoarthritis. Inulin is a prebiotic fiber that may improve gut health and reduce lipopolysaccharide (LPS), a marker of bacterial products in the blood that is linked to inflammation. In this trial, participants with knee osteoarthritis will be randomly assigned to receive either inulin or a placebo (maltodextrin) for 8 weeks. The study will measure changes in blood LPS levels, knee pain, and other markers of inflammation. The goal is to determine whether inulin supplementation can improve pain and reduce inflammation in people with knee osteoarthritis.

NCT Number	NCT07189585
Lead Sponsor	Yale University Collaborators: VA Connecticut Healthcare System, National Center for Complementary and Integrative Health (NCCIH)
Conditions	Knee Osteoarthritis
Enrollment	84 participants
Start Date	2026-11-01
Primary Completion	2027-07-31 (estimated)
Study Completion	2027-07-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-07