Postbiotics Ameliorate Cachexia in Patients With Non-small-cell Lung Cancer

This study aims to evaluate the efficacy of the oral postbiotic preparation JK-5G in improving body weight among patients with non-small-cell lung cancer (NSCLC)-related cachexia. By means of a randomized controlled trial, we will compare the between-group difference in body-weight changes between the JK-5G and placebo arms to clarify its nutritional therapeutic benefit.

NCT Number	NCT07185308
Lead Sponsor	Daping Hospital and the Research Institute of Surgery of the Third Military Medical University Collaborators: First Affiliated Hospital of Wenzhou Medical University, The First Hospital of Jilin University, Fujian Cancer Hospital, Zhongnan Hospital, National Cancer Center, China, Affiliated Hospital of Jiangnan University, Jiangsu Provincial People's Hospital, The First Affiliated Hospital of Zhengzhou University, Shanghai Changzheng Hospital, Zhengzhou University
Conditions	Cachexia; Cancer
Enrollment	150 participants
Start Date	2025-11-01
Primary Completion	2026-12-31 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-09-25