Sequential Imaging of Suspicion of Prostate Cancer Reducing Overdiagnosis and Unnecessary Biopsy With Timely Diagnosis of Significant Cancer

The goal of this clinical trial is to evaluate the safety and effectiveness of a novel diagnostic strategy for prostate cancer, in which men with a moderate risk of prostate cancer are monitored using PSA and MRI instead of immediate biopsy,. The main questions it aims to answer are: * Is it safe to delay biopsy, making sure that clinical significant prostate cancers are not often missed? * Does it reduce unnecessary biopsies and overtreatment?

NCT Number	NCT07180381
Lead Sponsor	St. Antonius Hospital
Conditions	Prostate Cancer
Enrollment	503 participants
Start Date	2025-05-14
Primary Completion	2031-01 (estimated)
Study Completion	2031-01 (estimated)
Updated on ClinicalTrials.gov	2025-12-04