Clinical Trial

UNC Cashew Sublingual Immunotherapy

Study acronym: CASCADES
Not Yet Recruiting Phase 2
View on ClinicalTrials.gov →
Summary
The CASCADES study will investigate the safety and efficacy of sublingual immunotherapy (SLIT) for the treatment of cashew allergy in children ages 1-11 years old. Primary efficacy will be assessed after 18 months of cashew SLIT. Lab studies and an oral food challenge after 6 months of cashew SLIT will help determine how quickly cashew SLIT begins to take effect.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-09-05; most recent amendment 2026-04-13.
Trial Details
NCT Number NCT07170540
Lead Sponsor University of North Carolina, Chapel Hill
Collaborators: Food Allergy Research & Education
Conditions Cashew Nut Allergy, Tree Nut Allergies
Enrollment 45 participants
Start Date 2026-06
Primary Completion 2028-12 (estimated)
Study Completion 2028-12 (estimated)
Updated on ClinicalTrials.gov 2026-04-14