Protease Regulation and Impact of Sodium as Mechanisms of Inflammation in IBD

The study looks at how eating salt affects gut health in people with Crohn's disease. The aim of the study is to find out whether eating more salt increases the breakdown of proteins in the gut and if this makes inflammation and symptoms worse. By studying the link between salt, gut bacteria and inflammation, the study hopes to improve diet advice for people with Crohn's disease. This research may help find specific foods that affect the disease and lead to better, more personalized nutrition plans.

NCT Number	NCT07169123
Lead Sponsor	McMaster University
Conditions	Crohns Disease
Enrollment	300 participants
Start Date	2025-08-18
Primary Completion	2029-09-01 (estimated)
Study Completion	2029-09-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-30