Clinical Trial

BILe Acid-gut Microbiome Axis MODification Through Diet Education for Colorectal Cancer Prevention

Study acronym: BILMOD
Recruiting
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Summary
This research study is a prospective, single-arm clinical trial to assess the effect of a dietary intervention for more plant-based and less animal-based food intake on secondary bile acid production, gut microbiota, circulating biomarkers and gene expression associated with colonic bile acid receptor activation and colorectal cancer.
Protocol Amendment History 3 changes
notable Primary completion pushed: 2027-03-31 -> 2027-06-18 2026-06-24
minor Completion pushed: 2028-03-01 -> 2028-06-01 2026-06-24
critical Recruitment opened 2026-05-19
Trial Details
NCT Number NCT07162337
Lead Sponsor Massachusetts General Hospital
Collaborators: National Cancer Institute (NCI)
Conditions Colorectal Cancer Prevention, Colorectal Adenoma
Enrollment 40 participants
Start Date 2026-06-18
Primary Completion 2027-06-18 (estimated)
Study Completion 2028-06-01 (estimated)
Updated on ClinicalTrials.gov 2026-06-23