Neurofeedback to Treat Depression - 2

This study tests the efficacy of a new psychotherapeutic strategy for reducing negative attention bias (and therefore depression severity) in participants with MDD. This real-time fMRI neurofeedback therapy uses cloud-based pattern classification to decode a patient's attentional state and dynamically modulate task stimuli (in a closed loop) based on this state.

NCT Number	NCT07159061
Lead Sponsor	University of Pennsylvania
Conditions	Major Depressive Disorder (MDD)
Enrollment	80 participants
Start Date	2025-11-21
Primary Completion	2028-11-21 (estimated)
Study Completion	2028-12-01 (estimated)
Updated on ClinicalTrials.gov	2025-12-04