Amyotrophic Lateral Sclerosis: A Multicenter Retrospective Observational Registry

This retrospective observational study will analyze de-identified clinical data from patients with amyotrophic lateral sclerosis (ALS) collected at multiple centers over 7 years. The primary objective is to describe disease progression using the ALS Functional Rating Scale-Revised (ALSFRS-R). Secondary objectives include evaluating survival, ventilatory decline, and correlations between available biomarkers (e.g., neurofilament light chain, cytokines) and disease trajectory. No new interventions or patient contact will occur.

NCT Number	NCT07143656
Lead Sponsor	Biocells Medical
Conditions	Amyotrophic Lateral Sclerosis (ALS), Amyotrophic Lateral Sclerosis & Other Neuromuscular Disorders
Enrollment	36 participants
Start Date	2021-05-13
Primary Completion	2028-08-13 (estimated)
Study Completion	2028-09-01 (estimated)
Updated on ClinicalTrials.gov	2025-08-28