Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery

This study aims to evaluate whether tranexamic acid (TXA), a medication that helps reduce bleeding, can decrease fluid drainage after breast reduction surgery. Participants will be randomly assigned to receive either intravenous TXA or no TXA during surgery. Additionally, one breast will receive TXA through the surgical drain, while the other will receive saline. This approach allows to compare the effects of TXA on fluid buildup and healing. The goal is to improve recovery and reduce complications after breast reduction surgery.

NCT Number	NCT07131592
Lead Sponsor	Massachusetts General Hospital
Conditions	Drain Output After Breast Reduction Surgery, Breast Reductions
Enrollment	160 participants
Start Date	2025-11-18
Primary Completion	2027-03-01 (estimated)
Study Completion	2027-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-01-16