Clinical Trial

Botensilimab, Balstilimab, and SBRT in Colorectal Cancer

Recruiting Early Phase 1
View on ClinicalTrials.gov →
Summary
This is a single-arm pilot feasibility study evaluating the combination of Botensilimab and Balstilimab with Radiation Therapy (RT) in Non-Microsatellite Instability High (MSI-H) or Proficient Mismatch Repair (pMMR) chemorefractory colorectal cancer (CRC) with liver metastasis.
Protocol Amendment History 1 change
critical Recruitment opened 2026-05-14
Trial Details
NCT Number NCT07128355
Lead Sponsor Massachusetts General Hospital
Collaborators: Agenus Inc.
Conditions Non-MSI-H or pMMR Colorectal Cancer With Liver Metastasis
Enrollment 15 participants
Start Date 2026-05-12
Primary Completion 2027-01-01 (estimated)
Study Completion 2027-09 (estimated)
Updated on ClinicalTrials.gov 2026-05-13