Metabolic Risk Assessment in Prepubertal Children With Congenital Hypothyroidism

We propose a multicenter prospective study to define the prevalence and severity score of metabolic syndrome in a prepubertal pediatric cohort with congenital hypothyroidism, compared to a healthy and normal-weight pediatric population. These data will help to define whether hypothyroidism can be considered a risk factor for the metabolic health of the pediatric population. The possible identification of an at-risk metabolic profile will provide useful information to optimize the diagnostic and monitoring pathway for affected children.

NCT Number	NCT07126353
Lead Sponsor	Buzzi Children's Hospital Collaborators: Federico II University, IRCCS Ospedale San Raffaele, Policlinico di Bari Giovanni XXIII, Azienda Ospedaliero Universitaria Policlinico Modena, Azienda Ospedaliero-Universitaria di Parma, Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna, Azienda Ospedaliera Sant'Anna, University Hospital Perugia, University of L'Aquila, Clinica Pediatrica Università di Novara, Santobono-Pausilpon Hospital, Azienda Ospedaliera Universitaria Policlinico "G. Martino", IRCCS Azienda Ospedaliero-Universitaria di Bologna, University Hospital of Ancona
Conditions	Congenital Hypothyroidism, Metabolic Syndrome
Enrollment	170 participants
Start Date	2025-09
Primary Completion	2026-07 (estimated)
Study Completion	2026-10 (estimated)
Updated on ClinicalTrials.gov	2025-08-17