The FINTEPLA as an Anti-SUDEP Therapy in Dravet Syndrome Project

This study investigates cerebrovascular reactivity (CVR) and functional brain connectivity in Dravet Syndrome (DS) patients with convulsive seizures. Using functional MRI (fMRI), we will define differences in brain responses to CO₂ changes before administration of the drug Fintepla (Baseline), with a library of healthy controls and with those obtained after administration of Fintepla (Day \~60). Changes in CVR and their relation to ventilatory responses will also be assessed during fMRI.

NCT Number	NCT07112365
Lead Sponsor	The University of Texas Health Science Center, Houston
Conditions	Dravet Syndrome
Enrollment	25 participants
Start Date	2026-04-27
Primary Completion	2027-09-30 (estimated)
Study Completion	2028-03-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-15