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[18F]AlF-NOTA-octreotide PET/MRI in Carotid Artery Disease

StatusRecruiting
PhasePhase 2
Started2025-03-18
View on ClinicalTrials.gov ↗
Record status
This record was last updated August 11, 2025 (before its estimated September 2026 completion). Its status may not reflect the trial's current state.

Amendment history

2025-08-05
minor
Study Status, Arms and Interventions v1
Re-verified, no change to tracked fields
2025-07-29
minor
Original filing
This clinical trial aims to evaluate whether \[¹⁸F\]AlF-OC PET/MRI can characterize and quantify inflammation in carotid atherosclerotic plaques. The study will assess if tracer uptake in culprit and non-culprit carotid arteries, measured by standardized uptake values (SUV), is associated with future cerebrovascular events. Specifically, it will examine whether \[¹⁸F\]AlF-OC uptake predicts the risk of recurrent ipsilateral TIA, amaurosis fugax, stroke, or other vascular complications. Participants will undergo \[¹⁸F\]AlF-OC PET/MRI and will be followed via telephone interviews at 90 days, 1 year, and 3 years after their initial stroke or TIA.
Trial Details
NCT Number NCT07104487
Lead Sponsor Universitaire Ziekenhuizen KU Leuven
Conditions Stroke (CVA) or TIA, Carotid Artery Plaque, Atherosclerosis Cardiovascular Disease, Carotid Arteriosclerosis
Enrollment 24 participants
Start Date 2025-03-18
Primary Completion 2026-09 (estimated)
Study Completion 2029-09 (estimated)
Updated on ClinicalTrials.gov 2025-08-11