White Matter Distortion and Dementia Biomarkers in Normal Pressure Hydrocephalus (NPH)

Idiopathic Normal Pressure Hydrocephalus (iNPH) is a progressive condition of the elderly that results in severe disability. iNPH can dramatically respond to Cerebral spinal fluid(CSF)-shunting where excess ventricular fluid is diverted from the brain. Not all patients with iNPH respond to CSF-shunting however. The reasons for this are uncertain. Aim 1: To understand if specific nerve pathways (white matter tracts) that are near ventricles are damaged in patients that respond to shunting as opposed to those that do not. Aim 2: Can we explain shunt non-responsiveness by screening for dementia like illnesses (neurodegeneration) using a large array of methods. Aim 3: To understand whether wearable activity and bed sleep monitors are palatable in a NPH population and to understand if these metrics relate to quality of life. Aim 4: To see whether self-administered digital cognitive assessments can measure improvements pre and post surgery.

NCT Number	NCT07103681
Lead Sponsor	Imperial College London Collaborators: Medical Research Council, Michael J. Fox Foundation for Parkinson's Research, University College, London, University of Edinburgh, King's College London
Conditions	Normal Pressure Hydrocephalus
Enrollment	100 participants
Start Date	2025-03-25
Primary Completion	2028-02 (estimated)
Study Completion	2029-02 (estimated)
Updated on ClinicalTrials.gov	2026-03-27