Total Neoadjuvant Therapy With Short Course Radiation Therapy in Gastric Cancer

Standard treatment for patients with early stage gastric cancer consists of perioperative chemotherapy and surgical resection. If radiation therapy is administered in the adjuvant setting, the radiated area is often large and associated with significant toxicity. In this study, the investigators propose the addition of short course radiation therapy (SCRT) to chemotherapy in the neoadjuvant setting. The investigators hypothesize that this regimen of Total Neoadjuvant Therapy (TNT) will result in a higher rate of complete response (both pathologic and clinical), with less toxicity.

NCT Number	NCT07101666
Lead Sponsor	Washington University School of Medicine
Conditions	Gastric Cancer
Enrollment	20 participants
Start Date	2026-10-31
Primary Completion	2031-04-30 (estimated)
Study Completion	2031-04-30 (estimated)
Updated on ClinicalTrials.gov	2026-08-06