Clinical Trial

Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

Study acronym: TIMELY-PLEX
Recruiting Phase 3
View on ClinicalTrials.gov →
Summary
The purpose of this research is to evaluate if early vs rescue Therapeutic Plasma Exchange (PLEX) treatment algorithm leads to better visual outcomes in severe Optic Neuritis and leads to better neurological disability outcomes in severe Transverse Myelitis.
Protocol Amendment History 1 change
notable Trial sites expanded: 24 -> 31 locations 2026-05-06
Trial Details
NCT Number NCT07100990
Lead Sponsor Mayo Clinic
Collaborators: Patient-Centered Outcomes Research Institute
Conditions Optic Neuritis, Myelitis, Myelitis, Transverse
Enrollment 382 participants
Start Date 2025-07-11
Primary Completion 2029-04-01 (estimated)
Study Completion 2031-04-30 (estimated)
Updated on ClinicalTrials.gov 2026-07-06