Clinical Trial

Pathways, Risk Factors, and mOleculeS to Prevent Early-onset Colorectal Tumors

Study acronym: PROSPECT
Recruiting Phase 1
View on ClinicalTrials.gov →
Summary
This research study is an open-label Phase 1 Exploratory/Pilot clinical trial to measure the effects of the incretin mimetic, tirzepatide, on tissue, urine, blood, and microbiome biomarkers associated with colorectal cancer risk and to understand the feasibility of this precision prevention trial approach for a future larger study.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-07-24; most recent amendment 2026-02-25.
Status change: Not Yet Recruiting → Recruiting 2026-02-25
Trial Details
NCT Number NCT07095517
Lead Sponsor Massachusetts General Hospital
Collaborators: National Cancer Institute (NCI), Cancer Research UK
Conditions Colorectal Cancer Prevention, Colorectal Adenoma
Enrollment 20 participants
Start Date 2026-02-24
Primary Completion 2027-03-31 (estimated)
Study Completion 2028-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-02-27