The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges

The inhalation of adenosine 5'-triphosphate (ATP) to evoke cough (ATP cough challenge) is becoming increasingly used as a tool to measure cough hypersensitivity in patients with chronic cough. However, the safety, feasibility, and repeatability of this procedure is not widely known. In this study, we will perform ATP cough challenges in healthy individuals and in patients with mild asthma and chronic cough to better understand the safety, feasibility, and repeatability of these challenges. Such information will guide the future conduct of ATP cough challenges to measure cough hypersensitivity and identify patients who may better respond to ATP-blocking therapies.

NCT Number	NCT07085975
Lead Sponsor	McMaster University
Conditions	Chronic Cough (CC), Asthma
Enrollment	33 participants
Start Date	2025-08-05
Primary Completion	2026-08-01 (estimated)
Study Completion	2026-10-01 (estimated)
Updated on ClinicalTrials.gov	2025-08-29