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Exploring the Role of the Prefrontal Cortex in Decision-Making

StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 4 months later Jul 2027 → Dec 2027
See other at-risk trials from University of Bern

Record History

  1. Primary completion pushed from Jul 2027 to Dec 2027
    • Study completion pushed from Oct 2027 to Feb 2028
    v2
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
University of Bern
73 trials monitored
See 3 trials at risk
Depression
3,055 trials monitored
See 173 trials at risk
The goal of this study is to examine whether high-definition transcranial direct current stimulation (HD-tDCS) can influence decision-making for emotionally valenced content in younger and older adults, with or without major depression. The main questions are: In healthy adults, does brain stimulation modulate how people respond to emotionally valenced content during a decision-making task? What happens in the brain during modulation? Do these effects differ between younger and older adults? In adults with depression, does brain stimulation help shift attention towards positive content during the task? What happens in the brain? Are these effects moderated by age (younger vs. older adults)? The investigators will compare participants who receive real stimulation to those who receive sham (placebo) stimulation. Participants will: Receive high-definition transcranial direct current stimulation (HD-tDCS) of the dorsolateral prefrontal cortex (DLPFC) Perform a decision-making task involving emotionally valenced words Complete the task while undergoing a brain scan using ultra-high field 7 Tesla magnetic resonance imaging (MRI) to measure brain activity
Trial Details
NCT Number NCT07080489
Lead Sponsor University of Bern
Collaborators: ki:elements
Conditions
(from sponsor)		 Depressive Disorder, Major Depressive Disorder, Healthy Volunteer, Aging
Related terms Depression, Major Depressive Disorder
Enrollment 444 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov