Omega-3D: Omega-3 for Diet-Driven Health Disparities

The goal of this clinical trial is to learn whether omega-3 fatty acid supplementation can reduce inflammation-related biomarkers and improve cardiovascular health in healthy adult volunteers with different genetic backgrounds. The main questions it aims to answer are: Does the response to omega-3 supplementation differ based on genetic variation in the FADS gene cluster (specifically rs174537)? Are changes in fatty acid ratios and inflammation markers greater among individuals of African ancestry compared to those of European ancestry? Researchers will compare omega-3 supplements to a placebo in a randomized, placebo-controlled crossover study to determine whether the Omega-3 supplementation is more effective in certain genetic and ancestry groups. Participants will take omega-3 supplements or a placebo daily for a defined period, then cross over to the other intervention. They will provide blood samples for analysis of fatty acid levels and inflammatory markers, complete questionnaires, and attend scheduled study visits.

NCT Number	NCT07078344
Lead Sponsor	University of Arizona Collaborators: National Center for Complementary and Integrative Health (NCCIH), Georgetown University
Conditions	Heart Health Markers, Cardiovascular Diseases, Omega 3 Fatty Acids
Enrollment	200 participants
Start Date	2025-07-31
Primary Completion	2029-05-31 (estimated)
Study Completion	2029-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-16