Clinical Trial

Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer

Recruiting Phase 2
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Summary
To learn about the effects of shorter RNI regimens in patients with breast cance who have had a lumpectomy or mastectomy and who are at higher risk for lower risk for the disease returning.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2025-07-15; most recent amendment 2026-05-19.
Status change: Not Yet Recruiting → Recruiting 2025-10-21
Trial Details
NCT Number NCT07076485
Lead Sponsor M.D. Anderson Cancer Center
Conditions Breast Cancer
Enrollment 768 participants
Start Date 2025-08-19
Primary Completion 2029-01-01 (estimated)
Study Completion 2031-01-01 (estimated)
Updated on ClinicalTrials.gov 2026-05-20