Prognostication of Recovery in Early Disorders of Consciousness Study

The goal of this study is to determine the extent to which neuroimaging metrics (e.g., functional MRI) are associated with the current level of consciousness, and future consciousness recovery, in patients with disorders of consciousness resulting from acute brain injury. The main questions this study aims to answer are: How do functional MRI findings (e.g., covert consciousness and network connectivity) associate with current level of consciousness? How do functional MRI findings (e.g., covert consciousness and network connectivity) associate with future recovery of consciousness? How does noxious stimulation affect the detection of covert consciousness and functional brain network connectivity?

NCT Number	NCT07074678
Lead Sponsor	University of Pennsylvania Collaborators: National Institute of Neurological Disorders and Stroke (NINDS)
Conditions	Disorder of Consciousness, Comatose, Coma; Prolonged, Vegetative State, Minimally Conscious State
Enrollment	150 participants
Start Date	2023-03-08
Primary Completion	2028-03-08 (estimated)
Study Completion	2029-03-08 (estimated)
Updated on ClinicalTrials.gov	2026-07-30