Effect of Mindfulness-based Neurofeedback for Adolescents With Elevated Repetitive Negative Thinking

This study will test the hypotheses that adolescent with repetitive negative thinking who at at-risk for serious mental illness will show greater default mode network (DMN) connectivity than healthy controls, at-risk adolescents will show greater changes in DMN connectivity than healthy controls, and that a longer session of mindfulness based neurofeedback will lead to greater reduction in DMN connectivity. To do so, 50 adolescents with elevated repetitive negative thinking and 50 matched healthy control participants will be enrolled into a double-blind randomized clinical trial of a session of mindfulness training with either active mindfulness-basde neurofeedback or sham mindfulness-based neurofeedback.

NCT Number	NCT07055217
Lead Sponsor	Massachusetts General Hospital Collaborators: National Institute of Mental Health (NIMH)
Conditions	Repetitive Negative Thinking, Neurofeedback
Enrollment	100 participants
Start Date	2025-11-04
Primary Completion	2027-04 (estimated)
Study Completion	2027-04 (estimated)
Updated on ClinicalTrials.gov	2026-05-19