Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor

This objective of this study is to document the safety and feasibility of electrical stimulation of the deep cerebellar nuclei for refractory tremor using the Medtronic Percept RC Deep Brain Stimulation System. The population will consist of patients that have either failed a prior intervention (Vim DBS or HIFU thalamotomy) or determined to not be suitable candidates for Vim DBS or HIFU thalamotomy because they have a cerebellar outflow or MS-related tremor. Those patients with a previous intervention, must have a prior diagnosis of ET, cerebellar outflow tremor, or MS-related tremor. Subjects without a previous intervention must have a diagnosis of cerebellar outflow tremor or MS-related tremor.

NCT Number	NCT07049003
Lead Sponsor	The Cleveland Clinic Collaborators: Raynor Cerebellum Project, Medtronic
Conditions	Tremor, Essential Tremor
Enrollment	12 participants
Start Date	2026-01-15
Primary Completion	2029-12-31 (estimated)
Study Completion	2029-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-10