Clinical Trial

Clinical Alternatives for Reducing Harm Using E-cigarettes

Study acronym: CARE
Enrolling by Invitation
View on ClinicalTrials.gov →
Summary
For patients in cancer care, quitting smoking is critical, but a significant portion of patients in cancer care refuse all components of tobacco treatment, even when offered free of charge. The proposed clinical trial will assess one harm reduction intervention, switching completely from cigarettes to e-cigarettes, among oncology outpatients who smoke and refuse traditional tobacco treatment. This study is a type 1 hybrid effectiveness-implementation trial among oncology outpatients at an NCI-designated cancer center who smoke and refuse all components of tobacco treatment (N=208).
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2025-06-18; most recent amendment 2026-05-06.
Status change: Recruiting → Enrolling by Invitation 2026-05-06
Status change: Not Yet Recruiting → Recruiting 2025-08-25
Trial Details
NCT Number NCT07039292
Lead Sponsor Medical University of South Carolina
Collaborators: National Cancer Institute (NCI), National Institutes of Health (NIH)
Conditions Smoking, E-Cig Use, Oncology
Enrollment 208 participants
Start Date 2025-08-25
Primary Completion 2029-05-31 (estimated)
Study Completion 2029-11-30 (estimated)
Updated on ClinicalTrials.gov 2026-05-08