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Minor6 versionsRe-verified since Apr 16, 2026, no change to tracked fieldsv112-v117
MinorStudy description expanded, about 32 wordsv111
MinorStart date changed from estimate of Dec 18, 2025 to Dec 11, 2025v110
MinorStart date: Dec 16, 2025 to Dec 18, 2025v109
MinorStart date: Dec 15, 2025 to Dec 16, 2025v108
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MinorStart date: Dec 14, 2025 to Dec 15, 2025v107
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MinorStart date: Oct 21, 2025 to Oct 22, 2025v71
MinorStart date: Oct 20, 2025 to Oct 21, 2025v70
MinorStart date: Oct 19, 2025 to Oct 20, 2025v69
MinorStart date: Oct 15, 2025 to Oct 19, 2025v68
Stopped: an ongoing trial was terminated, suspended or withdrawn.
Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Background:
Phosphodiesterase-4B (PDE4B) is a protein in the brain that may play a role in several mental health disorders. Researchers want to know if drinking alcohol increases the binding of a radioactive tracer to PDE4B in the brain because of increased activity and/or amount of the protein. This knowledge may help create new ways to treat people with alcohol use disorder (AUD).
Objective:
To learn if alcohol increases PDE4B activity in the brain.
Eligibility:
Healthy people aged 21 to 70 years who drink socially but do not have AUD. They must be enrolled in protocol 14-AA-0181"NIAAA Natural History Protocol".
Design:
Participants will have up to 4 clinic visits with up to 3 imaging scans of the brain; these will include 1 or 2 positron emission tomography (PET) scans and 1 magnetic resonance imaging (MRI) scan.
The first PET scan will be a baseline. Participants will receive a radioactive tracer through a tube inserted into a vein. A second tube will be inserted so that blood can be drawn during the scan. Participants will lie on a bed that slides into a doughnut-shaped machine. This visit will take about 6 hours.
For the next PET scan, participants will receive alcohol (ethanol) through a tube in a vein until they have a blood alcohol concentration that is equal to the legal driving limit. This is the same as 4 or 5 drinks for most people. After the scan, participants must remain at the clinic for a few hours until their blood alcohol drops. This visit will take 14 to 16 hours.
The MRI scan of the brain will take up to 2 hours in a separate clinic visit.