Clinical Trial

High Intensity Resistance Training + Creatine in Perimenopause

Study acronym: PERIHIRT
Completed
View on ClinicalTrials.gov →
Summary
Purpose: The aims of the study are to investigate the effects of high-intensity resistance training (HIRT) with or without creatine monohydrate (CM) supplementation on three key areas: muscle characteristics, brain health, and metabolism/protein dynamics. Participants: 51 healthy, perimenopausal women between 38-60 years old. Procedures: In a randomized double-blind, placebo-controlled design, participants will either consume creatine (CM), a placebo (PL), or no supplement (CON). CM and PL groups will be assigned a HIRT protocol, and the CON will do no training.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-06-16; most recent amendment 2026-03-09.
Status change: Recruiting → Completed 2026-03-09
Status change: Enrolling by Invitation → Recruiting 2025-06-18
Trial Details
NCT Number NCT07027800
Lead Sponsor University of North Carolina, Chapel Hill
Conditions Perimenopause
Enrollment 55 participants
Start Date 2025-06-02
Primary Completion 2025-12-15 (estimated)
Study Completion 2025-12-15 (estimated)
Updated on ClinicalTrials.gov 2026-03-11