Neuroimaging of Parkinson's

Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex. The investigators recently discovered a new brain system called the Somato-Cognitive Action Network (SCAN), which could be a primary locus of dysfunction in PD. Here, the investigators will use magnetic resonance imaging techniques in PD patients to test whether SCAN is critical for PD. The investigators will determine whether SCAN is connected to PD-relevant subcortical structures, and whether PD patients exhibit altered subcortical-to-SCAN connectivity. If successful, this work will identify SCAN as a specific circuit altered in PD patients that can serve as a new target for future neuromodulatory PD therapies.

NCT Number	NCT07024875
Lead Sponsor	Washington University School of Medicine Collaborators: National Institute of Neurological Disorders and Stroke (NINDS), Michael J. Fox Foundation for Parkinson's Research
Conditions	Parkinsons Disease (PD)
Enrollment	120 participants
Start Date	2025-08-01
Primary Completion	2031-01 (estimated)
Study Completion	2031-01 (estimated)
Updated on ClinicalTrials.gov	2026-04-13