Clinical Trial

Self-regulation of Real-time fMRI Brain Activity in Chronic Pain

Recruiting
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Record status
This record was last updated November 3, 2025 (before its estimated July 2026 completion). Its status may not reflect the trial's current state.
Summary
This study aims to explore the usefulness of self-regulation of brain activity in patients with fibromyalgia. Patients will use real-time functional magnetic resonance imaging (fMRI) neurofeedback to observe and regulate their own brain activity while applying mental strategies to reduce fibromyalgia pain. The study consists of 2 magnetic resonance imaging (MRI) visits that involve brain neuroimaging for fMRI neurofeedback tasks, as well as 8 weekly intervention sessions with a pain psychologist. Patients will be randomized to either Cognitive Behavioral Therapy (CBT) or Fibromyalgia Education groups.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-06-12.
Status change: Not Yet Recruiting → Recruiting 2025-10-31
Trial Details
NCT Number NCT07023523
Lead Sponsor Brigham and Women's Hospital
Collaborators: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Spaulding Rehabilitation Hospital
Conditions Fibromyalgia
Enrollment 36 participants
Start Date 2025-10-31
Primary Completion 2026-07 (estimated)
Study Completion 2026-07 (estimated)
Updated on ClinicalTrials.gov 2025-11-03